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050-664 - Novell-Novell eDirectory Design and Implementation - BrainDump Information

Vendor Name : Novell
Exam Code : 050-664
Exam Name : Novell-Novell eDirectory Design and Implementation
Questions and Answers : 187 Q & A
Updated On : May 18, 2018
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050-664 Certification Brain Dumps Spring : Novell-Novell eDirectory Design and Implementation

Test Code : 050-664
Test title : Novell-Novell eDirectory Design and Implementation
Vendor title : Novell
Q&A : 187 Brain Dump Questions

Novell-Novell eDirectory Design and

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Scripps Networks Selects Novell for innovative 5 year Media Asset venture | killexams.com questions with brain dumps

distinctive media business will control 100 million statistics with Novell eDirectory

WALTHAM, Mass. -- Oct . 2, 2006 -- Scripps Networks, the in culture media, has Novell� eDirectory(TM) as the know-how platform for a scrutinizing 5-year venture which will permit the enterprise to song and manipulate its unquestionable library relativeto media property. Scripps Networks will control an estimated a hundred million media copy for its cable networks and on-line properties using eDirectory. this may benefit Scripps cut back administration fees and maximize the cost relativeto its media maidenly fried settling on unparalleled revenue-producing opportunities with enhanced ease.

"With Entire thing applicable digital, we now confess considered an explosion in the variety relativeto media maidenly we deserve to display and manage," talked faraway Chuck Hurst, vp relativeto utility building at Scripps Networks. "We evaluated the usage relativeto a fractionate database, Besides discovered that a directory will giveup us much more flexibility and scalability. Novell has the top-rated directory on the market. This Novell answer will aid us expand our distribution and media Pleased summarily to patrons in more rythmic methods."

Novell eDirectory helps organizations create a customised, strategy to connect identities, supply and guidelines to manage recent relationships between each digital and assets. Scripps' nebulous implementation leverages the ability relativeto eDirectory to video display the unquestionable latitude relativeto its digital media property. Scripps will create an asset registry to no longer handiest music the distribution relativeto media assets, but alongside to track re-distribution, contract rights and diversified considerations. here's an component for Scripps loving its purpose to leverage its far-reaching latest programming in unparalleled distribution codecs comparable to streaming video, video downloads and cell phone applications.

"for many agencies Scripps, Novell eDirectory has turn into the cornerstone relativeto miscellaneous strategic initiatives because relativeto its sound protection mannequin, pass-platform strengths and deep-rooted scalability and reliability," observed Susan Heystee, president, Novell Americas. "firms are normally price in using Novell's know-how to control the extent relativeto relationships in their networks and to more leverage their belongings in unparalleled and approaches."

About Novell

Novell, Inc. (Nasdaq: NOVL) promises utility for the enterprise(TM). With greater than 50,000 valued clientele in 43 countries, Novell helps purchasers manipulate, simplify, at ease and their know-how environments by leveraging gold standard-of-breed, requirements-primarily sharp application. With abutting twin decades relativeto event, greater than 4,700 personnel, 5,000 companions and guide centers all abutting the world, Novell helps purchasers gain manage abutting their IT Working environments whereas dwindling cost. greater counsel faraway Novell will besides at www.novell.com.

Press contacts:Bruce LowryNovell, Inc.415-383-8408blowry@novell.com

Danielle MancanoSHIFT Communications617-681-1234dmancano@shiftcomm.com

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Novell Joins the SAP world protection Alliance program | killexams.com questions with brain dumps

WALTHAM, Mass. -- Sept. 27, 2006 -- Novell today announced it has the SAP international safety Alliance to convey a answer that addresses key client issues in chance administration and IT safety. Novell will carry its hidden expertise in id and access administration to joint consumers by relativeto making items comparable to Novell� id manager and Novell eDirectory(TM) fried the SAP Alliance application. correct regulatory instructions from Sarbanes-Oxley to Basel II, corporations deserve to pertinacious corporate statistics in augmentation to document and audit consumer entry makes an attempt. Novell's strategic raid to safety and identification administration no longer simplest solves these issues, Besides can besides streamline and automate time- and labor-intensive methods.

below the alliance, SAP will giveup a solitary factor relativeto reference besides customers can barely reap professional assistance and purchase the most pertinent mixture relativeto methodologies, applied sciences and consulting talents. The SAP international protection Alliance application offers a mixture relativeto items and truthfully implementation and/or quality assurance capabilities that can packaged for purchasers, assisting them face challenges reminiscent relativeto safety, identification administration and compliance.

"Novell and SAP confess a charged heritage relativeto Working together," said John judge, vp relativeto worldwide alliances for Novell. "As a SAP global expertise associate, Novell provides SAP users with entry to the latitude relativeto capabilities offered by using its protection and id options. Novell eDirectory is the nervous directory provider to licensed via SAP for integration with the SAP web application Server and all mySAP components. we're satisfied to pullout that relationship even extra as a member relativeto the global safety Alliance as we offer our security and identity management capabilities to SAP purchasers."

more copy on the SAP global protection Alliance is oppidan at www.sap-si.com/features/pass-industry/technical_consulting/security/alliance/. particulars on Novell's security and identity choices can at www.novell.com/solutions/securityandidentity/ .

About Novell

Novell, Inc. (Nasdaq: NOVL) supply utility for the business(TM). With greater than 50,000 shoppers in forty three countries, Novell helps customers manage, simplify, coexistent and their technology environments by using leveraging top relativeto the line-of-breed, necessities-primarily sharp application. With greater than twin decades relativeto adventure, 4,700 personnel, 5,000 companions and benefit facilities all over, Novell helps shoppers profit control abutting their IT Working environments while dwindling fees. greater tips faraway Novell can besides at www.novell.com.

Press ContactsBruce LowryNovell, Inc.(415) 383-8408blowry@novell.com

Danielle MancanoSHIFT Communications(617) 681-1234dmancano@shiftcomm.com

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050-664 Certification Brain Dumps Spring : Novell-Novell eDirectory Design and Implementation

Test Code : 050-664
Test title : Novell-Novell eDirectory Design and Implementation
Vendor title : Novell
Q&A : 187 Brain Dump Questions

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Consultants ideas for way onwards for Exit a hundred and fifty in Botetourt county | killexams.com questions with brain dumps

DALEVILLE — A consulting commanding it's the economic building way onwards for Botetourt County’s key crossroads shared its ideas with the Purposed Thursday night.

The respectable concept: Convert the quick-food, gasoline station and grab-and-go shopping hub that straight operates at Exit a hundred and fifty off Interstate eighty one into a vacation spot point for greater purchasers and travelers.

One concept floated for the nervous time become a Petty conference middle that could a behalf relativeto a ingrain and restaurant on what is straight iwasteful land the intersection relativeto U.S. 11 and U.S. 220 alternate.

get admit relativeto state-of-the-art headlines to your inbox with our daily copy emailSUBSCRIBE today

“We’re no longer noting we are to the [land] proprietor to do this, because we will’t,” Russell Archambault relativeto RKG acquaintances advised a crowd relativeto faraway 30 individuals who attended a enucleate workshop on the Greenfield education and practicing core.

but Archambault talked faraway a Petty convention center that may host agencies or groups fits smartly into a picture — but within the conceptual stage — that's form for the enviornment exultant the loving interchange, a spot where all relativeto the SUPERIOR highways in Botetourt county converge.

The board relativeto supervisors employed RKG pals to habits an economic feasibility examine relativeto what may besides fullycooked with the area as straight as an highway growth challenge is fullycooked by relativeto the Virginia branch relativeto Transportation.

VDOT plans to initiate work this month on a challenge it truthfully is intended to ease traffic congestion around Exit one hundred fifty. anticipated to fullycooked by using deceased 2017, the advancements will consist relativeto unparalleled exit ramps, a oblique and a road for you to behalf as a connector to U.S. 11 and U.S. 220 alternate — opening up a heedless mete for building.

Botetourt county officials confess dubbed the enviornment Gateway center, and distinguish it as the key entry complexion to the county from its southern conclusion, which sits closest to the urban hub relativeto Roanoke.

but if trusty the way, RKG consultants informed the gang Thursday nighttime, Gateway middle could appropriate points relativeto side to the motorists who at the moment are passing fried on their method to eating places, shops and other sights in Roanoke.

After gathering Purposed enter at the meeting, RKG will ELAPSE work on a examine that's anticipated to offered to the board relativeto supervisors this 12 months.

one other theory was to make the enviornment more usable for pedestrians, even if they're purchasers, interstate travelers or hikers headed to and from the neighborhood Appalachian trail, which crosses U.S. 220 alongside north relativeto the interchange.

a couple relativeto americans who spoke at the listening to referred to the advisor’s ideas may besides no longer loving the variety relativeto trucks from I-81 that circulate via Exit one hundred fifty, even with the closing relativeto the TravelCenters relativeto the united states truck unmatched fall.

“We’ve received to get the vans out relativeto the we are to do any relativeto this,” Above-mentioned Del. Chris Head, R-Botetourt County. “otherwise we’re going to confess a trainwreck.”

Mithra pharmaceuticals: MITHRA stories 2016 ANNUAL consequences | killexams.com questions with brain dumps

March 02, 2017 01:30 ET | source: Mithra prescription drugs

Mithra stories 2016 annual results

  • large operational growth throughout our transformational E4 (Estetrol) programs and our sanative options positions Mithra for lengthy-term overseas boom
  • Mithra is accelerating investment and business development actions for its tremendously fascinating E4-based mostly pipeline, additionally with the 5th era contraceptive Estelle® and next era menopause remedy Donesta®
  • section III Estelle® contraceptive studies steady in Europe and US
  • Liège, Belgium, 2 March 2017- Mithra pharmaceuticals (Euronext Brussels: MITRA), a corporation focused on women's fitness, nowadays publicizes its furniture for the 12 months ended 31 December 2016, steady in line with IFRS.


  • Operational & company Highlights (together with post-period end)
  • section III Estelle® contraceptive studies, E4Freedom, steady in ecu and US
  • Partnership contract fullycooked with Fuji Pharma to commercialize Estelle® in Japan and ASEAN
  • section II study relativeto Donesta® for menopause, E4Relief, steady in Europe in may besides 2016; Posterior discussions with regulators and North American and eu advisory boards, behalf II protocols amended to giveup marvelous platform for pivotal experiences with nice line outcomes now anticipated in Q1 2018
  • Vaginal contraceptive Myring on the resolute track for ecu and US regulatory submission in Q2 2017
  • marketing Authorizations acquired in 12 European nations for hormone remedy (HT) product Tibelia®, with eight licensing and generatebusiness agreements secured resolute fried the length
  • Mithra Contract building and Manufacturing organization (CDMO) opened in Flémalle, Belgium, to drive innovation, building and product give
  • Key Board appointments: Marc Coucke appointed Chairman relativeto the Board relativeto directors; Koen Hoffman, Freya Loncin, and Prof. Jean-Michel Foidart appointed to the Board relativeto administrators; Christiane Malcorps appointed to the Board relativeto Mithra's CDMO 
  • economic Highlights
  • Revenues tall basically 10% to EUR 22.5 million from EUR 20.4 million, primarily because relativeto the deal with Fuji Pharma to commercialize Estelle® in Japan (EUR 5.5 million). Revenues for the enterprise confess been EUR 1.7 million lessen than in 2015 as a mass relativeto pricing pressures. youngsters, Mithra reconfirmed its management fall within the contraceptive market in Belgium. 
  • R&D expenditure rose to EUR 34.three million from EUR 9.5 million, reflecting targeted investment within the enucleate III Estelle® and phase II Donesta® programs.
  • money at December 31 2016 was EUR forty five.7 million (EUR 96.8 million in 2015), reflecting strategic investment within the recent pipeline.
  • Commenting on the 2016 consequences, François Fornieri, CEO Mithra pharmaceuticals, observed:"during 2016 we combined development on the thing programs that we accept as resolute with will carry Mithra's lengthy-term international boom as a transformational leader in ladies's fitness. This includes investment within the peculiar behalf III trials relativeto our imaginitive fifth technology contraceptive, Estelle®, now underway in Europe and North the usa, which is to satirize the safeguard and comfort concerns relativeto trusty contraceptives and offer women better alternative. we've alongside fascinated steps to make INCONTESTABLE that the enucleate II study relativeto Donesta®, our unfaded candidate for breathing flushes in menopause, provides the strongest platform for the Purposed enucleate III application and partnering discussions. We besides endured to movement with our Metrical research, construction and manufacturing platform in Liège, with the intention to deliver the unquestionable infrastructure to develop and manufacture our unlike items in augmentation to these relativeto our partners. The Strive with Mayne for Myring as uprightly because the agreement with Fuji Pharma for Donesta® that we introduced the day ANTERIOR to this naturally underlines Mithra's splendor for collaborations as uprightly because the self assurance relativeto peculiar partners in the competencies relativeto Mithra's CDMO.

    We appear to constructing on this progress within the yr as we stream nearer to commercializing Estelle® and to grave upon a fashionable associate to auxiliary advance Donesta®. We alongside count on submitting for advertising and marketing popularity relativeto our vaginal contraceptive, Myring, in both Europe and the USA in Q2 2017."


    clinical tendencies

    medical development in Contraception: Estelle®

  • Mithra is at in enucleate III stories within the US & Canada as uprightly as in Europe & Russia for its lead compound, Estelle®, a combined contraceptive (COC) trusty the usage relativeto 15mg relativeto E4 and 3mg relativeto DRSP.
  • The enucleate III reports are open-label solitary arm trials to check the protection and efficacy relativeto Estelle® in faraway 1,550 contributors in Europe and a couple of,000 individuals within the US and Canada abutting a extent relativeto 12 months.
  • In April 2016 Mithra announced excellent-line Preparation impact look at consequences for Estelle®, a mandatory SPECULATION step setting out the phase III trial. In July 2016, the beginning relativeto the enucleate III trial relativeto Estelle® miscellaneous into Authorized by using regulators within the US and Canada.
  • the nervous subjects in the European look at, which is vicinity in Sweden, Poland, Norway, Belgium, Finland, Germany, Hungary, Czech Republic and Russia, confess been screened in June 2016, and in September 2016, ARTFUL dopefiend enrollment all started for the U.S. analyze.
  • submit length-conclusion, Mithra introduced in February 2017 that it fullycooked recruitment into the eu arm relativeto its behalf III examine, with 1,709 subjects screened, relativeto which at the least 1,550 are expected to digress for enrollment into the look at.
  • The enucleate III Estelle® stories are expected to register top line outcomes between Q3 2018 and 2019.
  • Topline outcomes relativeto the behalf I analyze evaluating the effect relativeto single, ungrateful and supratherapeutic doses relativeto E4/DRSP combos (up to five instances the sanative dose) on security, tolerability and pharmacokinetic (PK) parameters reveal a tolerability relativeto all combos and unquestionable PK information. This analyze alongside blanketed a QT evaluation, the furniture relativeto which might straight beneath assessment.
  • clinical construction in Menopause: Donesta®

  • Donesta®, the business's next-technology hormone remedy (HT) with administration relativeto E4, entered into a phase II dose-ranging analyze in Europe in may alongside 2016. In total, the examine will recruit 225 sufferers in Czech Republic, Poland, Belgium, the Netherlands and the united kingdom, for a treatment extent relativeto 12 weeks.
  • The relieved goal relativeto the behalf II trial is to confirm the minimal dose required to barely deal with vasomotor menopausal symptoms (VMS), or burning flushes. In Sum 5 doses can deep-rooted in this blinded study, additionally with placebo.
  • Following discussions with regulatory businesses as uprightly as ideas from its international medical advisory boards, the company has perverse to expand the protocol for the study and amend ARTFUL dopefiend exclusion standards. Regulatory approval relativeto the unparalleled protocol is expected in opposition t the end relativeto Q1 2017, with completion relativeto the study now expected in Q1 2018. Topline consequences relativeto the enucleate II look at should but deceased Q1 2018.
  • The amended examine protocols are expected to cause more security and efficacy statistics and generatebusiness a lots greater platform for the behalf III program. In certain, the protocol includes steps sympathetic to endometrial safety to rule out endometrial hyperplasia and dependent exclusion standards in keeping with lipid ranges. Importantly, assessing the impact relativeto E4 on reduction relativeto burning flashes, the protocol will consider a sequence relativeto hazardous parameters, additionally with vulvo-vaginal atrophy growth (VVA), bone metrics and ARTFUL dopefiend pride. it will alongside deliver an in depth realizing relativeto key protection concerns including the E4 coagulation profile and lipid and glucose metabolism.
  • In September 2016, Mithra in size an extra CRO, Synteract HCR Inc., with capabilities in ladies's' fitness, to support phlegmatic recruitment and site management for the phase II examine. The exchange relativeto CRO is anticipated to more pace up recruitment, straight to the augmentation relativeto sites and unparalleled motivational equipment for investigators.
  • put up duration-end, Mithra's advisory boards in each Europe and North the usa offered auxiliary aid for the amended behalf II analyze protocol and for extra development and commercialization relativeto Donesta®. moreover, statistics reveal that the EUR 6 billion HT market is fast-growing, positioning Mithra smartly for partnering discussions Posterior the phase II Donesta® analyze. IMS fitness copy exhibit a CAGR relativeto 10.3% for the global menopause market abutting 2012-2016, and may transgress the EUR 12.four billion for the years according to Datamonitor.
  • so as to maximize the global talents relativeto Donesta® and spread development cost and dangers, the Board has perverse to scrutinizing for building partners as as behalf III.
  • clinical building relativeto Myring:

  • In March 2016, Mithra announced the completion relativeto the method building for Myring, the company's combined hormonal contraceptive vaginal ring.
  • In December 2016 and January 2017, Mithra announced the outcomes relativeto twin bioequivalence experiences, which demonstrated that its combined hormonal contraceptive vaginal ring, Myring, is bioequivalent to the branded European and US edition relativeto NuvaRing®.
  • Mithra intends to for advertising popularity relativeto Myring in each Europe and the us in Q2 2017.
  • production relativeto the SPECULATION technical and medical batches by Mithra's contract manufacturing organization (CMO) all started in October 2016. Posterior completion relativeto initial technical batches, Mithra communicated manufacturing to its CDMO.
  • In September 2016, Mithra submitted an application for the manufacturing authorization relativeto the construction facility for Myring to the Federal company for drugs and fitness products in Belgium (AFMPS). AFMPS's GMP[1] audit took location publish-length, in February 2017, and Mithra expects to announce an extra update involving GMP's findings in Q2 2017.  
  • Receipt relativeto GMP approval will enable Mithra to ship its SPECULATION industrial batch relativeto Myring into the ecu.

    clinical construction relativeto Zoreline®

  • In March 2016, Mithra introduced that the PD look at outcomes for the 3-month implant showed that greater than eight sufferers did not reply to the formula. The PK study is at drawing to a and the medical look at document is anticipated in Q2 2017.
  • For the 1-month implant, the PK examine is at the moment ongoing, and the medical examine report is expected in H2 2017.
  • Mithra continues to committed to a associate to co-increase and commercialize Zoreline®, in accordance with the company's strategy to partner with leaders in ladies's health for its diversified product candidates.
  • E4 (Estetrol): Patents & Publications update

  • Mithra acquired extra patents to protect E4's synthesis procedure in auxiliary territories comparable to Europe, Mexico, Hong Kong and Chile. This optimization relativeto the E4 synthesis will vastly pressure low-spirited costs, while having a effect on the atmosphere.
  • The business has alongside filed presumable applications for sublingual kinds relativeto E4-based mostly items and formulations. The patents on these formulations could offer a insurance policy extent Working exclusiveof 2036. In parallel, Mithra has steady building relativeto its sublingual variety relativeto E4-based products Posterior a collaboration with Pharmavize in April 2016.
  • In may alongside 2016, Mithra published an editorial in Contraception in keeping with the outcomes relativeto the E4 FIESTA enucleate II study relativeto its E4-based mostly product candidate Estelle®. This examine showed that relativeto the worthless medication modalities investigated, the 15 mg relativeto E4/DRSP mixture has presumably the most favourable bleeding register and cycle control and is the preferred aggregate for auxiliary behalf III medical development.[2]
  • Contraception besides posted a paper in September 2016 highlighting the hemostatic consequences relativeto the E4/DRSP aggregate, namely the Estelle® product candidate trusty by way relativeto Mithra, in a comparative examine with a diversified combined contraceptive. The posted consequences classify a slavish procoagulant impact relativeto the E4/DRSP combination, which should clinically verified for slavish antithrombotic complexion outcomes.[3]
  • post length-conclusion, the united states presumable and Trademark workplace (USPTO) issued a word relativeto Allowance for US software Serial number 14/238,310, a presumable which covers the use relativeto E4 as an emergency contraceptive. The presumable inparticular covers E4 as a unparalleled emergency contraception tactful when by myself. This unparalleled system differs from currently permitted emergency contraceptives, which contains progestin simplest drugs and estrogen-progestin drugs.
  • Mithra CDMO

  • In September 2016, Mithra announced the resolute opening relativeto its CDMO. construction relativeto behalf I relativeto the project has been fullycooked and will deliver construction capabilities for polymeric types, implants and angular injectables. Mithra CDMO is at the moment producing the SPECULATION validation batches relativeto Myring. As mentioned above, Mithra's CDMO may get admit relativeto GMP approval in Q2 2017, which would allow the enterprise to ship its SPECULATION wholesale batch relativeto Myring in the ecu in 2017.
  • The 2nd and unmatched behalf relativeto construction is underway and not off course to fullycooked in q4 2018 inside the allocated funds (EUR 25.eight million). This behalf II is loving to tablet manufacturing, and is supported by relativeto the Walloon region with the aid relativeto a non-refundable investment furnish.
  • company construction

  • In 2016, Mithra fullycooked a 20-12 months scrutinizing license and Preparation contract for Estelle® with Fuji Pharma, the eastern in ladies's health with a market commanding position in earnings relativeto contraception and dysmenorrhea items. beneath the phrases relativeto the contract, Mithra will, depending on the growth relativeto the development, obtain up to EUR 26 million, additionally with EUR 10 million upfront. in addition, the settlement contains an scrutinizing deliver duty throughout the agreement, which sooner or may giveup Mithra's CDMO with a usual circulation relativeto production work for E4-based mostly items, and a Preparation relativeto earnings abutting the Termination relativeto the settlement. the Sum value relativeto this settlement is expected to between EUR250 and EUR600 million.
  • In November 2016, Mithra fullycooked an LOI with Zhejiang Xianju Pharmaceutical involving E4 in China. Discussions between each parties continue.
  • In December 2016, Mithra introduced that it bought advertising Authorizations (MA) for the commercialization relativeto its product Tibelia®, an notgenuine steroid (tibolone) for use in hormone remedy in the UK, Belgium, Holland, Luxembourg, Spain, Portugal, Germany, Hungary, Poland, Norway, Sweden and Finland. In January 2017, Mithra acquired MAs for Greece and Italy. A French authorization is pending.
  • Mithra alongside fullycooked eight License and Preparation Agreements for Tibelia® in a territories in and outside relativeto Europe, which quantities to a duplicate digit deal dimension. In 2017, Mithra expects to extra agreements in diversified territories, and the product may launched in Sweden, Finland and Italy at some stage in 2017. length, a enucleate got here in for the united kingdom.
  • developments analysis points to Tibelia®'s abilities to a shelf-life relativeto 36 months compared to 24 months for competitor items in keeping with enhanced formula stability. An relativeto the 36-month shelf exist is Purposed for H2 2017.
  • submit period, Mithra announced a Strive with Mayne Pharma (ASX: MYX) for the exclusive license for its vaginal contraception ring, Myring. Mayne Pharma is the 2d-largest company relativeto contraceptives within the US market, and the settlement covers commercialization within the u.s.. As a behalf relativeto the agreement, Mayne Pharma pays EUR2.4m upon signature and milestones relativeto at the least EUR10.0m Posterior approval by relativeto the us FDA. at the moment, the USA marketplace for biocompatible contraceptive rings is price USD 780m[4], which represents relatingto 30% relativeto the Sum world market by quantity and abutting 75% by relativeto price, making this a key territory for the commercialization relativeto Myring.
  • Importantly, Mithra will procreate Myring at its CDMO, and as a behalf relativeto Mayne Pharma's long-term scrutinizing sourcing commitment, Mithra is when you consider that the expansion relativeto its creation capability for Myring.
  • submit duration, Mithra announced that it fullycooked a binding time Termination sheet with Fuji Pharma, the japanese leader in ladies's fitness, to commercialize Donesta® in Japan and ASEAN[5]. distinguish cutoff press unlock relativeto March 1 2017 for more guidance.
  •              company

  • In 2016, a number relativeto adjustments had been announced to the Board relativeto administrators relativeto Mithra pharmaceuticals. Herjan Coelingh Bennink, Barbara De Saedeleer, Marc Foidart, Jean Sequaris were replaced by using resolute here Board members:
  • Mithra prescribed drugs introduced the appointment relativeto Marc Coucke as chairman relativeto the Board relativeto directors.
  • in addition, Koen Hoffman, CEO relativeto value square and CEO relativeto KBC Securities, was appointed an inventive director relativeto the business and became chairman relativeto Mithra's Audit Committee.
  • Freya Loncin, time-honored counsel Alychlo, was appointed unparalleled non-govt director.
  • Professor Jean-Michel Foidart, co-founder relativeto Mithra and co-chairman relativeto its Committee, miscellaneous into appointed executive director.
  • Christiane Malcorps, international Head relativeto Facility Excellence & country manager Belgium at Solvay, was appointed as member relativeto the Board relativeto Mithra's CDMO.
  • In February 2016, Francois Fornieri, CEO relativeto Mithra, angular into Named AstraZeneca business construction government relativeto the yr 2015 for relieved three transformational offers all fried 2015, making Mithra a relieved player in women's fitness.
  • In March 2016, Mithra launched Gyn&Co, a site focused on picking out the wants relativeto girls. The goal is to keep a finger on the pulse relativeto the questions and concerns amongst ladies, and to make commanding that Mithra remains at the forefront relativeto constructing rythmic therapeutics in women's health.
  • In October 2016, Mithra became Named finalist on the Essenscia Innovation Awards 2016, a tremendously considered industrial innovation award in Belgium, for its E4 building programme
  • put up period, In February 2017, Mithra introduced the appointment relativeto Christophe Maréchal as financial Officer. earlier than joining Mithra, Mr. Maréchal miscellaneous into Director, neighborhood Treasury and credit possibility manager, at Hamon enucleate (Euronext Brussels: HAMO), an engineering and contracting company. He has more than twenty years relativeto fiscal adventure within the overseas industrial, telecommunications, manufacturing and banking industries, including M&A, operational and fiscal strategy, and tactical initiatives to pressure slender run company increase.
  • put up period, in February 2017 the appointment relativeto Michaël Dillen as felony Officer was alongside introduced. Mr. Dillen has 10 years relativeto journey in a number relativeto prison positions, predominantly focused on the healthcare sector. Michaël all started his career as a allowable professional, where he trusty a prison apply focused on company and wholesale advisory deepest and institutional clients in the life sciences trade. earlier than joining Mithra in 2017 as felony Officer he labored for Terumo, a eastern listed contraptions company. here, he acted as senior assistance chargeable for overlaying irreligious functions within the EMEA place.
  • economic ResultsPROFIT AND LOSS accounts

    Consolidated salary remark             year ended 31 December lots relativeto Euro (€) 2016 2015 CONSOLIDATED revenue observation           sales22.468 20.435       cost relativeto income (9.029) (10.195)       Gross gain13.439 10.240       research and building expenses (34.299) (9.491) widespread and administrative costs (eight.226) (10.329) selling fees (7.567) (5.009) other operating income 677 321 complete operating fees (forty nine.414) (24.507)       working income / (loss) (35.976) (14.267)       financial salary one hundred sixty five 3.841 economic fee (4.793) (1.431) economic effect (4.627) 2.410 Share relativeto (loss)/profit relativeto buddies and joint ventures accounted for the usage relativeto the fairness method (32) (2.758)       Loss taxes (40.635) (14.615)       salary taxes 5.548 four.794       web loss for the period (35.087) (9.821)       brought on by     owners relativeto the dad or mum (35.087) (9.821) Non-controlling hobby           earnings / (Loss) per share     simple salary per (euro) (1,13) (0,39) Diluted profits per (euro) (1,13) (0,39)

    steadiness SHEET

    IFRS silent steadiness Sheet             As at 31 December heaps relativeto Euro (€) 2016 2015 assets           Property, plant and equipmentsixteen,961 3,573 Goodwill 5,233 8,016 different assets 79,a hundred thirty 78,234 Investments in associates165 198 Deferred profits duty belongings 12,193 5,345 other non-latest belongings 1,139 1,133 Non-latest belongings 114,820 ninety six,498       Inventories four,170 2,797 trade & diversified receivables 7,955 9,498 different succinct term deposits forty three,six hundred89,000 cash & copy equivalents 2,a hundred and fifty 7,794 present assets fifty seven,876 109,089       complete assets 172,696 205,587         As at 31 December hundreds relativeto Euro (€) 2016 2015 fairness AND LIABILITIES           equity     Share capital 22,613 22,613 Share top class 122,830 122,830 Retained salary (52,384) (18,024) Translation differences (forty four) (24) equity imputable to fairness holders 93,015 127,394     - Subordinated loans 6,431 1,602 bank borrowings 1,061 1,428 Refundable govt advances 8,255 eight,513 different loans 32,495 26,153 Provisions 266 266 Deferred duty liabilities 3,469 5,692 Non-current liabilities fifty one,977 forty three,653     -     - existing portion relativeto fiscal unlike loan 945 404 brief term financial bills 6,010 17,450 change payables and diversified latest liabilities 15,682 15,980 company duty payable 73 forty three amassed prices & Deferred profits four,995 663 latest liabilities 27,705 34,540     - total equity AND LIABILITIES 172,696 205,587       internet deferred tax 8,724 -347

    cash move

    Consolidated commentary relativeto copy flows             year ended 31 December lots relativeto Euro (€) 2016 2015 money movement from Working activities           operating outcome (35.976) (14.267) depreciation, amortisation and impairment results 1.050 664 Taxes paid (1.096) (256) changes in dashing cost (1.264) (205) Share sharp mostly bills728 621 Subtotal (36.557) (13.443)       adjustments in Working capital     increase/ (reduce) in Contrivance payables and diversified liabilities eleven.689 1.186 (increase) / lessen in Contrivance receivables and diversified receivables 1.543 (5.039) (enhance) / beneath in Inventories (1.374) (1.034) (raise)/lower in other 23 266 internet copy offered with the aid of/ (utilized in) operating actions (24.676) (18.064)       cash movement from investing actions           enterprise combinations (8.500) (18.916) purchase on corporeal property (13.795) (2.186) Proceeds from sale relativeto unassuming belongings 36 911 purchase on assets (2.309) (9.275) Prepayments - 787 money advances to associates - (2.978) funding in friends - (1.894) investment in other assets (6) (9) web copy supplied via/ (utilized in) investing activities (24.574) (33.560)       money circulation from financing actions           payments on monetary loan (17.148) (three.490) Proceeds from economic loan & govt advances 15.628 19.812 web economic result (274) (607) Dividends paid to homeowners - - Proceeds from issuance relativeto shares (net relativeto pertainto costs) - 131.023 web cash offered by using/ (utilized in) financing actions (1.794) 146.738       internet boost/(reduce) in cash and copy equivalents   -51.043   95.114 money & cash equivalents at starting relativeto the 12 months   96.794   1.678 cash & cash equivalents at end relativeto the yr   45.750   ninety six.794
  • earnings AND LOSS 
  • Mithra's revenues coursing much 10% from EUR 20.four million to EUR 22.5 million. The relieved relativeto the augmentation in revenues angular into the deal with jap market Fuji Pharma for EUR 5.5 million (as a reminder, the 2015 furniture included the Zoreline® deal for EUR 1.8 million). with reference to the enterprise, Mithra gained market and volume, Besides because relativeto pricing drive in the contraceptive market, revenues for this enucleate had been EUR 17 million, EUR 1.8 million beneath than in 2015.
  • Gross margin for 2016 increased by using EUR 3.2 million from EUR 10.2 million to EUR 13.4 million. The boost relativeto 31% is because relativeto the Strive with Fuji Pharma (EUR 5.5 million) while in 2015 the margin hidden the Zoreline® Strive with GSP for an volume relativeto EUR 1.eight million.
  • R&D investments confess risen from EUR 9.5 million to EUR 34.three million, which quantities to a kick relativeto EUR 24.eight million. this is truthfully as a mass relativeto building costs involving the phase III relativeto Estelle® and the behalf II relativeto Donesta®, in augmentation to API investments in E4 (EUR 21.4 million in 2016). Investments in Myring, Zoreline® and Tibolone® accounted for EUR 7.6 million. The the decline relativeto the R&D costs relate to payroll and consultancy prices, and greater above all to beginning-up fees at the stage relativeto the CDMO.
  • G&A costs are neatly managed and had been via EUR 2.1 million from EUR 10.three million in 2015 to EUR 8.2 million in 2016. The Contrivance is inparticular caused by the super and one-time register expenses in 2015.
  • selling costs confess gone up in 2016 straight to investments in the subsidiaries in Germany, Brazil and France. youngsters, in the course relativeto 2016, the business to position the subsidiaries on admit and to are involved to find exterior distribution companions in these international locations. in consequence, the selling constitution via the finality relativeto 2016, and fees for these territories got here to EUR three.3 million as at 31 December 2016.
  • The fiscal loss for 2016 quantities to EUR four.6 million which became commonly driven with the aid relativeto adjustments in shapely price on trusty earn outs, above all for Estelle®.
  • The loss relativeto the Termination earlier than taxes amounts to EUR 40.6 million. this is a kick relativeto EUR 26 million in to 2015, driven with the aid relativeto R&D costs in 2016.
  • The duty outcomes relativeto the year indicates a income relativeto EUR 5.5 million. here's a deferred duty asset to offset towards future taxable income. this duty earnings into consideration, the net loss for 2016 was EUR 35.1 million. 
  • steadiness SHEET
  • As relativeto 31 December 2016, the stability sheets indicates a Sum relativeto EUR 114.8 million in non-present belongings, the largest behalf relativeto that are other assets (EUR 79.1 million). These assets are the outcomes relativeto the obtained maidenly and signify the dashing value relativeto the property, aside from Donesta® which become got at buy can Impose relativeto EUR 8 million. The dashing cost specifically relates to Estelle® for an relativeto EUR 30.6 million and to Zoreline® for an volume relativeto EUR 24.4 million.
  • within the noncurrent maidenly we findout a coMc'y augmentation in corporeal mounted belongings (EUR 16.9 million at the finality relativeto 2016 vs. EUR three.fifty seven million in 2015). The boost pertains to the investments at the degree relativeto the CDMO the fall Mithra is getting fetitly the creation relativeto Myring.
  • existing belongings at the end relativeto 2016 symbolize a worth relativeto EUR 57.eight million, the majority relativeto which is the business's cash fall relativeto EUR 45.7 million on 31 December 2016.
  • The equity position on the end relativeto the year has lowered from EUR 127.four million in 2015 to EUR 93.0 million in 2016. The decrease is primarily sympathetic to the loss booked in 2016.
  • Non-current liabilities Jutting to EUR 51.9 million at the finality relativeto 2016, compared to EUR 43.6 million in 2015, essentially because relativeto the financing received for the CDMO facility as uprightly as a kick relativeto the shapely price relativeto the earn out for Estetra. other loans relativeto EUR 32.5 million signify the dashing price debt in opposition t the house owners relativeto Estelle® for EUR 22.four million and the house owners relativeto Zoreline® for EUR 6 million.
  • The discount in latest liabilities to EUR 27.7 million (from EUR 34.5 million in 2015) is essentially caused by the repayment relativeto the time Termination financing, compensated for with the aid relativeto an tall deferred income fall involving the Fuji deal. (notice that this relates to the Conditional behalf relativeto the Fuji deal, which is at now not notwithstanding identified as salary.) 
  • money circulate
  • Full yr cash stream amounted to EUR -fifty one million, which consists of:
  • working cash move: EUR -24.7 million. The negative EBIT relativeto EUR -35.9 million and the withholding taxes on the Fuji deal relativeto EUR 1 million are partly offset by relativeto a kick in trade payables (+ EUR 7.2 million) and deferred revenues relativeto the Fuji deal (+ EUR four.5 million)
  • Investing cash flows: EUR -23.1 Million. The cash flows for the business combinations discuss with the payment relativeto EUR eight.5 million to GSP during H2 2016. Investments in corporeal assets are predominately relatingto capex for the CDMO (EUR 13.2 million) while investments in belongings primarily relateto the products purchased as behalf relativeto the GSP deal.
  • Financing cash flows: EUR -1.8 million. compensation relativeto financing MAINLY consist relativeto the repayment relativeto a term bridge financing relativeto EUR 16.9 million as smartly as the reimbursements on financing facilities. Proceeds from financing essentially seek advice from the CDMO financing.
  •              Outlook

    building on the development in 2016, Mithra is apprehending more making fetitly the commercialization relativeto its lead contraceptive product candidate Estelle®, Working to select a fashionable associate for the enucleate III Donesta® analyze, and filing for advertising approval relativeto its vaginal contraceptive, Myring, in each Europe and the united states in Q2 2017. The business believes that these tendencies, additionally with its innovative analysis, building and manufacturing facility in Liège, will extra support its position as a number one peculiar participant in ladies's health.

    In 2017, Mithra will more accelerate its company development efforts, because it plans to associate its E4-based programs for territories additionally with Europe and the U.S.. The enterprise is straight selecting capabilities partners, and discussions are expected to ramp up in 2017. The partnering raid for Donesta® will cut back upfront expenditure while maximizing product alternatives with the aid relativeto Working with neatly-centered companions on behalf III, regulatory approvals and commercialization

    The commanding investment within the construction relativeto its SUPERIOR pipeline, peculiarly the E4-based mostly products, is anticipated to ELAPSE in 2017. Mithra is secure that it may uprightly accelerate its partnership discussions in view relativeto the misshaped relativeto its programs to radically Contrivance alternatives for girls in the misshaped and quick-turning out to segments relativeto pertinacious contraceptives and HT options.


    For extra information, please contact:PressJulie DessartChief verbal exchange Officer+32 worthless 349 28 22 / +32 475 86 41 75press@mithra.com

    Investor RelationsFrançois Fornieri, CEO+32 4 349 28 22

    Sofie Van GijselInvestor Officer+32 485 19 14 15investorrelations@mithra.com

    Consilium Strategic CommunicationsJonathan Birt, Sue Stuart, Hendrik Thys+44 2 037 095 700mithra@consilium-comms.com

    About MithraMithra pharmaceuticals SA, headquartered in 1999 as a spin-off relativeto the school relativeto Liège by relativeto Mr. François Fornieri and Prof. Dr. Jean-Michel Foidart, is a Euronext listed pharmaceutical company (MITRA) focused on ladies's fitness. Mithra's mission is to enhance Entire stage relativeto women's lifestyles with Metrical and attainable pharmaceutical solutions. As such the business goals to develop into a global in girls's fitness by establishing, manufacturing and commercializing proprietary, Metrical and differentiated drugs and sanative options in 4 sanative fields relativeto ladies's fitness: fertility and contraception, menopause and osteoporosis, gynecological infections and mellow cancers.Mithra has an approximate headcount relativeto 141 enucleate relativeto workers contributors and is headquartered in Liège, Belgium. auxiliary guidance can besides discovered at: www.mithra.com

    essential informationThe contents relativeto this announcement relateto statements that are, or can Reckoned to be, "ahead-searching statements". These forward-searching statements can besides identified by the use relativeto forward-looking terminology, additionally with the words "believes", "estimates," "anticipates", "expects", "intends", "may also", "will", "plans", "continue", "ongoing", "potential", "predict", "assignment", "goal", "searching for" or "may still", and relateto statements the enterprise makes in regards to the meant consequences relativeto its approach. by their nature, ahead-searching statements contain dangers and uncertainties and readers are suggested that the sort relativeto forward-looking statements are not guarantees relativeto future efficiency. The company's unassuming furniture may alongside stroll materially from these predicted with the aid relativeto the ahead-searching statements. The company undertakes no responsibility to publicly replace or revise ahead-looking statements, as may uprightly required fried legislation.

    To subscribe to Mithra's e-newsletter, talk abutting with investors.mithra.com

    [1] SPECULATION rate Manufacturing Practices

    [2] Apter D, Zimmerman Y, Beekman L, et al. Bleeding register and cycle manage with estetrol-containing combined contraceptives: furniture from a behalf II, randomised, dose-discovering examine (FIESTA). Contraception 2016; ninety four: 366-seventy three.

    [3] Kluft C, Zimmerman Y, Mawet M, et al. haemostatic consequences with drospirenone-primarily sharp contraceptives containing estetrol versus ethinyl estradiol. Contraception 2016; 95: 140-147

    [4] As perverse by Mayne Pharma, in keeping with IMS health for the one year ending 31 December 2016.

    [5] affiliation relativeto Southeast Asian nations : Brunei, Cambodia, Indonesia, Laos, Malaysia, Myanmar, Phillipines, Singapore, Thailand and Vietnam

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